A crash involving a tractor-trailer and a car shut down a section of Highway 401 in both directions for most of Monday.

The crash happened around 10:30 a.m. shutting down the highway between Cobourg and Colborne, Ontario Provincial Police say.

Police say the driver of the tractor-trailer was heading west when his trailer became dislodged. The trailer went over the median and into the path of an oncoming eastbound car.

Both the driver of the tractor-trailer and the female driver of the car have been taken to a local hospital. Their injuries are not believed to be life-threatening.

The eastbound lanes reopened shortly after 3:30 p.m., the westbound lanes opened shortly after 6 p.m.

Police continue to investigate the crash.