Eating a grapefruit or drinking its juice can be a great way to get vitamin C, but it can also be dangerous when taking certain prescription drugs.

A study says grapefruit juice can interact with more than 85 oral medications, with almost 45 of them leading to severe, even deadly, consequences.

Pharmacologist David Bailey of Western University in London, Ont., says adverse effects can include sudden death, acute kidney or respiratory failure, and gastrointestinal bleeding.

Bailey says medications affected by grapefruit include cholesterol-lowering statins, some heart drugs, and certain anti-psychotic and pain medicines.

Grapefruit contains a chemical that interferes with an enzyme that controls how drugs are absorbed through the intestines, resulting in a potentially toxic dose of medication.

Other citrus fruits that contain the chemical to some degree include limes, pomelos and Seville oranges, which are often used in marmalade.

“Many of the drugs that interact with grapefruit are highly prescribed and are essential for the treatment of important or common medical conditions,” says Bailey, lead author of the study in Monday’s issue of the Canadian Medical Association Journal.

The list of medications include:

    Alfentanil (oral)
    Amiodarone
    Apixaban
    Atorvastatin
    Buspirone
    Clopidogrel
    Crizotinib
    Cyclosporine
    Darifenacin
    Dasatinib
    Dextromethorphan
    Domperidone
    Dronedarone
    Eplerenone
    Erlotinib
    Erythromycin
    Everolimus
    Felodipine
    Fentanyl (oral)
    Fesoterodine
    Halofantrine
    Ketamine (oral)
    Latatinib
    Lovastatin
    Lurasidone
    Maraviroc
    Nifedipine
    Nilotinib
    Oxycodone
    Pazopanib
    Pimozide
    Primaquine
    Quinine
    Quetiapine
    Quinidine
    Rilpivirine
    Rivaroxaban
    Silodosin
    Simvastatin
    Sirolimus
    Solifenacin
    Sunitinib
    Tacrolimus
    Tamsulosin
    Ticagrelor
    Triazolam
    Vandetanib
    Venurafenib
    Verapamil
    Ziprasidone

With files from 680News