Writer and director Nora Ephron died on Tuesday in New York at the age of 71, succumbing to leukemia.

Ephron directed, produced or wrote more than 15 Hollywood movies, including When Harry Met Sally, Sleepless in Seattle and You’ve Got Mail.

Meg Ryan was turned into a worldwide star through her roles in those three films. Ephron also worked with Meryl Streep, most notably in the whistleblower drama Silkwood, which she wrote, and Julie & Julia which she directed. Streep starred as famed chef and author, Julia Child in the latter.

Ephron received three Oscar nominations for her screenwriting but never took home the Academy Award.